Drug interactions
Itraconazole + Nintedanib
Severity: Moderate
Itraconazole and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase nintedanib exposure, raising the likelihood of gastrointestinal effects such as diarrhoea and nausea, and hepatotoxicity.
What this interaction means in plain words
Itraconazole and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Nintedanib belongs to Oncology.
Why it happens
Itraconazole inhibits P-glycoprotein, and CYP3A4 to a lesser degree, reducing nintedanib efflux and clearance.
What to do
Monitor for adverse effects and liver enzymes, and manage with supportive care, dose reduction or interruption of nintedanib as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Itraconazole with Nintedanib?
MediHelp rates the interaction as moderate. Itraconazole and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase nintedanib exposure, raising the likelihood of gastrointestinal effects such as diarrhoea and nausea, and hepatotoxicity.
How serious is the interaction between Itraconazole and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and liver enzymes, and manage with supportive care, dose reduction or interruption of nintedanib as needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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