Drug interactions
Itraconazole + Pacritinib
Severity: Major
Itraconazole and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases pacritinib concentrations, which raises the risk of QT prolongation, arrhythmia, bleeding and diarrhea. Pacritinib labeling advises against strong CYP3A4 inhibitors.
What this interaction means in plain words
Itraconazole and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Pacritinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by itraconazole decreases the metabolism of pacritinib, a CYP3A4 substrate.
What to do
Avoid concomitant use where possible and consider a non-azole antifungal. If unavoidable, monitor ECG and electrolytes and be ready to reduce or interrupt pacritinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Itraconazole with Pacritinib?
MediHelp rates the interaction as major. Itraconazole and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases pacritinib concentrations, which raises the risk of QT prolongation, arrhythmia, bleeding and diarrhea. Pacritinib labeling advises against strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and consider a non-azole antifungal. If unavoidable, monitor ECG and electrolytes and be ready to reduce or interrupt pacritinib.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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