Drug interactions
Itraconazole + Tasimelteon
Severity: Minor
Itraconazole and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise tasimelteon concentrations, potentially increasing adverse effects such as somnolence, headache and abnormal dreams. Clinical data with itraconazole specifically are limited.
What this interaction means in plain words
Itraconazole and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Tasimelteon belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces tasimelteon metabolism.
What to do
No dose adjustment is routinely required. Monitor for increased adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Itraconazole with Tasimelteon?
MediHelp rates the interaction as minor. Itraconazole and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may raise tasimelteon concentrations, potentially increasing adverse effects such as somnolence, headache and abnormal dreams. Clinical data with itraconazole specifically are limited.
How serious is the interaction between Itraconazole and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required. Monitor for increased adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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