Drug interactions
Itraconazole + Vilazodone
Severity: Moderate
Itraconazole and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases vilazodone exposure, which may heighten serotonergic and gastrointestinal adverse effects.
What this interaction means in plain words
Itraconazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Vilazodone belongs to Central Nervous System.
Why it happens
Itraconazole inhibits CYP3A4, which contributes to vilazodone metabolism.
What to do
Limit vilazodone to 20 mg daily during strong CYP3A4 inhibitor use if needed. Monitor for serotonin toxicity and return to the usual dose after itraconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Itraconazole with Vilazodone?
MediHelp rates the interaction as moderate. Itraconazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole increases vilazodone exposure, which may heighten serotonergic and gastrointestinal adverse effects.
How serious is the interaction between Itraconazole and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit vilazodone to 20 mg daily during strong CYP3A4 inhibitor use if needed. Monitor for serotonin toxicity and return to the usual dose after itraconazole is stopped.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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