Drug interactions
Ivacaftor + Ivermectin
Severity: Minor
Ivacaftor and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite weakly inhibit P-glycoprotein and may modestly increase ivermectin exposure. The effect is expected to be small given ivermectin's wide therapeutic index.
What this interaction means in plain words
Ivacaftor and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Ivermectin belongs to Anti Parasitic.
Why it happens
Ivacaftor inhibits P-glycoprotein, reducing ivermectin efflux.
What to do
No dose adjustment is usually necessary. Monitor for increased ivermectin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Ivermectin?
MediHelp rates the interaction as minor. Ivacaftor and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its metabolite weakly inhibit P-glycoprotein and may modestly increase ivermectin exposure. The effect is expected to be small given ivermectin's wide therapeutic index.
How serious is the interaction between Ivacaftor and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually necessary. Monitor for increased ivermectin adverse effects.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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