Drug interactions
Ivacaftor + Posaconazole
Severity: Moderate
Ivacaftor and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases ivacaftor exposure, raising the risk of adverse effects such as elevated transaminases and headache. Ivacaftor may also modestly raise concentrations of P-gp substrates such as posaconazole.
What this interaction means in plain words
Ivacaftor and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of ivacaftor, and ivacaftor weakly inhibits P-gp.
What to do
Reduce ivacaftor dosing frequency per product labeling for strong CYP3A4 inhibitors. Monitor liver enzymes and for posaconazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Posaconazole?
MediHelp rates the interaction as moderate. Ivacaftor and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases ivacaftor exposure, raising the risk of adverse effects such as elevated transaminases and headache. Ivacaftor may also modestly raise concentrations of P-gp substrates such as posaconazole.
How serious is the interaction between Ivacaftor and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce ivacaftor dosing frequency per product labeling for strong CYP3A4 inhibitors. Monitor liver enzymes and for posaconazole adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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