Drug interactions
Ivacaftor + Progesterone
Severity: Minor
Ivacaftor and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A4 substrate, and progesterone is at most a weak inhibitor. Any increase in ivacaftor exposure is expected to be small.
What this interaction means in plain words
Ivacaftor and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Progesterone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition by progesterone reducing ivacaftor clearance.
What to do
No dose change is usually needed; monitor for ivacaftor adverse effects such as headache, dizziness and elevated liver enzymes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Progesterone?
MediHelp rates the interaction as minor. Ivacaftor and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a CYP3A4 substrate, and progesterone is at most a weak inhibitor. Any increase in ivacaftor exposure is expected to be small.
How serious is the interaction between Ivacaftor and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for ivacaftor adverse effects such as headache, dizziness and elevated liver enzymes.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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