Drug interactions
Ivermectin + Lomitapide
Severity: Minor
Ivermectin and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a P-glycoprotein inhibitor and may increase systemic exposure to ivermectin. Because ivermectin has a wide therapeutic margin, the effect is expected to be small, though adverse effects could be more frequent.
What this interaction means in plain words
Ivermectin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-gp mediated efflux of ivermectin, increasing its absorption and tissue levels.
What to do
Dose reduction is usually unnecessary for short ivermectin courses. Watch for neurological or gastrointestinal adverse effects, especially with repeated dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ivermectin with Lomitapide?
MediHelp rates the interaction as minor. Ivermectin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide is a P-glycoprotein inhibitor and may increase systemic exposure to ivermectin. Because ivermectin has a wide therapeutic margin, the effect is expected to be small, though adverse effects could be more frequent.
How serious is the interaction between Ivermectin and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose reduction is usually unnecessary for short ivermectin courses. Watch for neurological or gastrointestinal adverse effects, especially with repeated dosing.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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