Drug interactions
Ivermectin + Tacrolimus
Severity: Minor
Ivermectin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is a P-glycoprotein substrate and may inhibit ivermectin efflux, slightly raising ivermectin exposure. Clinical consequences are not established.
What this interaction means in plain words
Ivermectin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible competition for P-glycoprotein efflux between tacrolimus and ivermectin.
What to do
No routine adjustment is needed; monitor tacrolimus trough levels if ivermectin is used repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ivermectin with Tacrolimus?
MediHelp rates the interaction as minor. Ivermectin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus is a P-glycoprotein substrate and may inhibit ivermectin efflux, slightly raising ivermectin exposure. Clinical consequences are not established.
How serious is the interaction between Ivermectin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor tacrolimus trough levels if ivermectin is used repeatedly.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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