Drug interactions
Ixazomib + Lopinavir
Severity: Minor
Ixazomib and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, inhibits CYP3A4, but strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. No clinically important interaction is expected.
What this interaction means in plain words
Ixazomib and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Lopinavir belongs to Anti Virals.
Why it happens
Lopinavir/ritonavir inhibits CYP3A4, which contributes little to ixazomib clearance.
What to do
No dose adjustment is needed; monitor routinely for ixazomib toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Ixazomib with Lopinavir?
MediHelp rates the interaction as minor. Ixazomib and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lopinavir, given with ritonavir, inhibits CYP3A4, but strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. No clinically important interaction is expected.
How serious is the interaction between Ixazomib and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routinely for ixazomib toxicity.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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