Drug interactions
Ixazomib + Nevirapine
Severity: Moderate
Ixazomib and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce ixazomib exposure through CYP3A induction, risking loss of anti-myeloma activity. Strong CYP3A inducers substantially lower ixazomib exposure, and nevirapine is a weaker inducer, so the effect is likely smaller but uncertain.
What this interaction means in plain words
Ixazomib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ixazomib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing the metabolic clearance of ixazomib.
What to do
Prefer a non-inducing antiretroviral regimen during ixazomib therapy. If nevirapine must continue, monitor disease response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ixazomib and Nevirapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Ixazomib with Nevirapine?
MediHelp rates the interaction as moderate. Ixazomib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce ixazomib exposure through CYP3A induction, risking loss of anti-myeloma activity. Strong CYP3A inducers substantially lower ixazomib exposure, and nevirapine is a weaker inducer, so the effect is likely smaller but uncertain.
How serious is the interaction between Ixazomib and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiretroviral regimen during ixazomib therapy. If nevirapine must continue, monitor disease response closely.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
