Drug interactions
Ixazomib + Rucaparib
Severity: Minor
Ixazomib and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A inhibitor in vitro and could raise ixazomib levels. Ixazomib is not strongly affected by CYP3A inhibitors, so the effect is expected to be small.
What this interaction means in plain words
Ixazomib and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, which may modestly reduce ixazomib metabolism.
What to do
No dose adjustment is needed; monitor for ixazomib toxicities such as thrombocytopenia, neuropathy and gastrointestinal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ixazomib with Rucaparib?
MediHelp rates the interaction as minor. Ixazomib and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A inhibitor in vitro and could raise ixazomib levels. Ixazomib is not strongly affected by CYP3A inhibitors, so the effect is expected to be small.
How serious is the interaction between Ixazomib and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for ixazomib toxicities such as thrombocytopenia, neuropathy and gastrointestinal effects.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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