Drug interactions
Labetalol + Propofol
Severity: Moderate
Labetalol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and labetalol blocks alpha and beta receptors. Together they can cause greater hypotension and bradycardia during induction or sedation.
What this interaction means in plain words
Labetalol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive hypotensive effects through vasodilation and reduced cardiac output and blunted compensatory sympathetic responses.
What to do
Monitor blood pressure and heart rate continuously and titrate propofol slowly, reducing the dose if needed. Have fluids and vasopressors available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Propofol
Frequently asked questions
Can I take Labetalol with Propofol?
MediHelp rates the interaction as moderate. Labetalol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and labetalol blocks alpha and beta receptors. Together they can cause greater hypotension and bradycardia during induction or sedation.
How serious is the interaction between Labetalol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously and titrate propofol slowly, reducing the dose if needed. Have fluids and vasopressors available.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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