Drug interactions
Lacosamide + Lopinavir
Severity: Minor
Lacosamide and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir (boosted with ritonavir) inhibits CYP3A4, one of several pathways involved in lacosamide clearance. Lacosamide exposure may rise modestly, but lacosamide has multiple elimination routes so the effect is generally small.
What this interaction means in plain words
Lacosamide and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated lacosamide metabolism, which is only one of several elimination pathways.
What to do
No empirical dose change is needed; monitor for dizziness, ataxia and PR prolongation if lacosamide is used with boosted lopinavir, and adjust the lacosamide dose to response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lacosamide with Lopinavir?
MediHelp rates the interaction as minor. Lacosamide and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lopinavir (boosted with ritonavir) inhibits CYP3A4, one of several pathways involved in lacosamide clearance. Lacosamide exposure may rise modestly, but lacosamide has multiple elimination routes so the effect is generally small.
How serious is the interaction between Lacosamide and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for dizziness, ataxia and PR prolongation if lacosamide is used with boosted lopinavir, and adjust the lacosamide dose to response and tolerability.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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