Drug interactions
Lacosamide + Stiripentol
Severity: Minor
Lacosamide and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes including CYP3A4 and CYP2C19, which contribute to lacosamide metabolism. Lacosamide levels may change in either direction, though a large effect is unlikely. Both drugs are used in epilepsy and can add to dizziness and somnolence.
What this interaction means in plain words
Lacosamide and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4 and CYP2C19 by stiripentol may alter lacosamide metabolism.
What to do
Monitor seizure control and adverse effects such as somnolence and ataxia when starting or stopping stiripentol, and adjust the lacosamide dose by response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Lacosamide with Stiripentol?
MediHelp rates the interaction as minor. Lacosamide and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits and induces several CYP enzymes including CYP3A4 and CYP2C19, which contribute to lacosamide metabolism. Lacosamide levels may change in either direction, though a large effect is unlikely. Both drugs are used in epilepsy and can add to dizziness and somnolence.
How serious is the interaction between Lacosamide and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and adverse effects such as somnolence and ataxia when starting or stopping stiripentol, and adjust the lacosamide dose by response.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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