Drug interactions
Lacosamide + Zonisamide
Severity: Moderate
Lacosamide and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on sodium channels, and lacosamide can lengthen the PR interval. Combined use may increase risk of conduction abnormalities, particularly in patients with cardiac disease.
What this interaction means in plain words
Lacosamide and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lacosamide belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Additive sodium channel blockade with slowed cardiac conduction.
What to do
Consider an ECG before and after titrating lacosamide in patients with conduction disease or other risk factors. Watch for syncope, dizziness or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Zonisamide?
MediHelp rates the interaction as moderate. Lacosamide and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on sodium channels, and lacosamide can lengthen the PR interval. Combined use may increase risk of conduction abnormalities, particularly in patients with cardiac disease.
How serious is the interaction between Lacosamide and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG before and after titrating lacosamide in patients with conduction disease or other risk factors. Watch for syncope, dizziness or bradycardia.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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