Drug interactions
Lanthanum carbonate + Magnesium hydroxide
Severity: Moderate
Lanthanum carbonate and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents bind to other compounds in the gut and may interfere with each other's handling. Co-administration can reduce lanthanum's phosphate binding and complicates the interpretation of phosphate control. Magnesium also adds to the cation load in patients with renal disease.
What this interaction means in plain words
Lanthanum carbonate and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lanthanum carbonate belongs to Miscellaneous; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Cation binding and competition within the gastrointestinal tract alter the availability of lanthanum and magnesium.
What to do
Separate administration of the antacid and lanthanum by at least 2 hours. Monitor serum phosphate and magnesium in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Lanthanum carbonate
Frequently asked questions
Can I take Lanthanum carbonate with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Lanthanum carbonate and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents bind to other compounds in the gut and may interfere with each other's handling. Co-administration can reduce lanthanum's phosphate binding and complicates the interpretation of phosphate control. Magnesium also adds to the cation load in patients with renal disease.
How serious is the interaction between Lanthanum carbonate and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration of the antacid and lanthanum by at least 2 hours. Monitor serum phosphate and magnesium in patients with renal impairment.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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