Drug interactions
Lapatinib + Silodosin
Severity: Moderate
Lapatinib and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase silodosin concentrations, raising the risk of hypotension and dizziness. The effect is predicted from mechanism rather than shown directly, and lapatinib is a weaker inhibitor than agents such as ketoconazole.
What this interaction means in plain words
Lapatinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Silodosin belongs to Genitourinary.
Why it happens
Lapatinib inhibits CYP3A4 and P-glycoprotein, potentially reducing silodosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms, and consider an alternative alpha-blocker if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Silodosin?
MediHelp rates the interaction as moderate. Lapatinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase silodosin concentrations, raising the risk of hypotension and dizziness. The effect is predicted from mechanism rather than shown directly, and lapatinib is a weaker inhibitor than agents such as ketoconazole.
How serious is the interaction between Lapatinib and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and consider an alternative alpha-blocker if hypotension develops.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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