Drug interactions
Lasmiditan + Leflunomide
Severity: Minor
Lasmiditan and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, and teriflunomide, the active metabolite of leflunomide, is a BCRP substrate. Teriflunomide exposure could rise, though the clinical significance of intermittent lasmiditan use is likely small.
What this interaction means in plain words
Lasmiditan and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Leflunomide belongs to Musculoskeletal.
Why it happens
Inhibition of BCRP-mediated efflux may increase teriflunomide exposure.
What to do
No routine change is needed; monitor for leflunomide adverse effects such as liver enzyme elevation if lasmiditan is used frequently.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Leflunomide?
MediHelp rates the interaction as minor. Lasmiditan and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro, and teriflunomide, the active metabolite of leflunomide, is a BCRP substrate. Teriflunomide exposure could rise, though the clinical significance of intermittent lasmiditan use is likely small.
How serious is the interaction between Lasmiditan and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for leflunomide adverse effects such as liver enzyme elevation if lasmiditan is used frequently.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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