Drug interactions
Leflunomide + Losartan
Severity: Minor
Leflunomide and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C9, which converts losartan to its active metabolite E-3174. Antihypertensive effect could be modestly reduced, though the clinical importance is not established.
What this interaction means in plain words
Leflunomide and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leflunomide belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
Teriflunomide inhibits CYP2C9, reducing formation of active E-3174.
What to do
Monitor blood pressure after starting leflunomide. Adjust the losartan dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Leflunomide with Losartan?
MediHelp rates the interaction as minor. Leflunomide and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C9, which converts losartan to its active metabolite E-3174. Antihypertensive effect could be modestly reduced, though the clinical importance is not established.
How serious is the interaction between Leflunomide and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting leflunomide. Adjust the losartan dose if control worsens.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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