Drug interactions
Leflunomide + Piroxicam
Severity: Minor
Leflunomide and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide's active metabolite may slightly increase exposure to piroxicam. Both drugs can also cause hepatic and gastrointestinal effects, so additive adverse effects are possible.
What this interaction means in plain words
Leflunomide and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leflunomide belongs to Musculoskeletal; Piroxicam belongs to Musculoskeletal.
Why it happens
Teriflunomide, the active metabolite of leflunomide, may inhibit CYP2C9, which metabolizes piroxicam.
What to do
No dose change is usually required. Monitor liver enzymes as routinely done for leflunomide and watch for NSAID gastrointestinal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Piroxicam?
MediHelp rates the interaction as minor. Leflunomide and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide's active metabolite may slightly increase exposure to piroxicam. Both drugs can also cause hepatic and gastrointestinal effects, so additive adverse effects are possible.
How serious is the interaction between Leflunomide and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor liver enzymes as routinely done for leflunomide and watch for NSAID gastrointestinal effects.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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