Drug interactions
Leniolisib + Tenofovir alafenamide
Severity: Minor
Leniolisib and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may raise exposure to substrates of this transporter. Tenofovir alafenamide is mainly a P-gp and BCRP substrate, so intestinal absorption could rise modestly. Clinical significance is likely small.
What this interaction means in plain words
Leniolisib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leniolisib belongs to Miscellaneous; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Leniolisib inhibits intestinal BCRP efflux, potentially increasing tenofovir alafenamide absorption.
What to do
No routine dose change is needed; monitor for tenofovir-related renal or bone adverse effects in patients with existing renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Leniolisib and Tenofovir alafenamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Leniolisib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP and may raise exposure to substrates of this transporter. Tenofovir alafenamide is mainly a P-gp and BCRP substrate, so intestinal absorption could rise modestly. Clinical significance is likely small.
How serious is the interaction between Leniolisib and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for tenofovir-related renal or bone adverse effects in patients with existing renal impairment.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
