Drug interactions
Lenvatinib + Ondansetron
Severity: Moderate
Lenvatinib and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lenvatinib and ondansetron can prolong the QT interval. Combined use may increase the risk of clinically significant QT prolongation and torsades de pointes.
What this interaction means in plain words
Lenvatinib and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Check ECG and correct potassium, magnesium and calcium before and during combined therapy. Use the lowest effective ondansetron dose or choose an alternative antiemetic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Ondansetron?
MediHelp rates the interaction as moderate. Lenvatinib and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lenvatinib and ondansetron can prolong the QT interval. Combined use may increase the risk of clinically significant QT prolongation and torsades de pointes.
How serious is the interaction between Lenvatinib and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium, magnesium and calcium before and during combined therapy. Use the lowest effective ondansetron dose or choose an alternative antiemetic if the QTc becomes prolonged.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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