Drug interactions
Leriglitazone + Rosuvastatin
Severity: Moderate
Leriglitazone and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leriglitazone may increase rosuvastatin exposure through BCRP inhibition. This could increase the risk of statin-related myopathy.
What this interaction means in plain words
Leriglitazone and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leriglitazone belongs to Central Nervous System; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of BCRP efflux transporter increases rosuvastatin absorption and reduces elimination.
What to do
Use the lowest effective rosuvastatin dose and monitor for muscle pain, weakness or elevated CK.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Leriglitazone with Rosuvastatin?
MediHelp rates the interaction as moderate. Leriglitazone and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leriglitazone may increase rosuvastatin exposure through BCRP inhibition. This could increase the risk of statin-related myopathy.
How serious is the interaction between Leriglitazone and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and monitor for muscle pain, weakness or elevated CK.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
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