Drug interactions
Letermovir + Montelukast
Severity: Minor
Letermovir and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits several metabolic enzymes and may raise montelukast concentrations. Montelukast has a broad safety margin, so the clinical consequence is probably small.
What this interaction means in plain words
Letermovir and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Montelukast belongs to Respiratory.
Why it happens
Letermovir inhibits CYP3A4 (and CYP2C8 to a degree), reducing montelukast clearance.
What to do
No empirical dose change is required; monitor for montelukast adverse effects such as neuropsychiatric symptoms during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Montelukast?
MediHelp rates the interaction as minor. Letermovir and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits several metabolic enzymes and may raise montelukast concentrations. Montelukast has a broad safety margin, so the clinical consequence is probably small.
How serious is the interaction between Letermovir and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required; monitor for montelukast adverse effects such as neuropsychiatric symptoms during co-therapy.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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