Drug interactions
Letermovir + Progesterone
Severity: Moderate
Letermovir and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir moderately inhibits CYP3A4 and may increase progesterone concentrations. This could produce more sedation or bleeding pattern changes.
What this interaction means in plain words
Letermovir and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Progesterone belongs to Endocrine.
Why it happens
Letermovir inhibits CYP3A4-mediated progesterone metabolism.
What to do
Monitor for progestogenic adverse effects during letermovir therapy and adjust progesterone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Letermovir and Progesterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Progesterone
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Progesterone?
MediHelp rates the interaction as moderate. Letermovir and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir moderately inhibits CYP3A4 and may increase progesterone concentrations. This could produce more sedation or bleeding pattern changes.
How serious is the interaction between Letermovir and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects during letermovir therapy and adjust progesterone dose if needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
