Drug interactions
Letermovir + Teriflunomide
Severity: Minor
Letermovir and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide may increase letermovir plasma concentrations, which could raise the likelihood of letermovir adverse effects such as gastrointestinal upset and peripheral edema. The effect is predicted from transporter inhibition and has limited clinical documentation.
What this interaction means in plain words
Letermovir and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide may inhibit hepatic uptake transporters such as OATP1B1/3, reducing letermovir clearance.
What to do
No routine dose change is needed; monitor for letermovir adverse effects when the drugs are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Teriflunomide?
MediHelp rates the interaction as minor. Letermovir and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide may increase letermovir plasma concentrations, which could raise the likelihood of letermovir adverse effects such as gastrointestinal upset and peripheral edema. The effect is predicted from transporter inhibition and has limited clinical documentation.
How serious is the interaction between Letermovir and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for letermovir adverse effects when the drugs are used together.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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