Drug interactions
Leuprolide + Osilodrostat
Severity: Moderate
Leuprolide and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and leuprolide may add to this effect. Risk is higher with hypokalemia, since osilodrostat can also lower potassium.
What this interaction means in plain words
Leuprolide and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and repeat after starting therapy, and keep potassium and magnesium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Leuprolide with Osilodrostat?
MediHelp rates the interaction as moderate. Leuprolide and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and leuprolide may add to this effect. Risk is higher with hypokalemia, since osilodrostat can also lower potassium.
How serious is the interaction between Leuprolide and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after starting therapy, and keep potassium and magnesium normal.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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