Drug interactions
Leuprolide + Oxaliplatin
Severity: Moderate
Leuprolide and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide-induced androgen deprivation can prolong the QT interval, and oxaliplatin has been linked to QT prolongation and arrhythmias. The combination may add to the risk of torsades de pointes, particularly with electrolyte losses from chemotherapy.
What this interaction means in plain words
Leuprolide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation, possibly aggravated by oxaliplatin-related electrolyte disturbances.
What to do
Check a baseline ECG and monitor the QTc during treatment. Keep potassium, magnesium and calcium within normal ranges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Leuprolide with Oxaliplatin?
MediHelp rates the interaction as moderate. Leuprolide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide-induced androgen deprivation can prolong the QT interval, and oxaliplatin has been linked to QT prolongation and arrhythmias. The combination may add to the risk of torsades de pointes, particularly with electrolyte losses from chemotherapy.
How serious is the interaction between Leuprolide and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor the QTc during treatment. Keep potassium, magnesium and calcium within normal ranges.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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