Drug interactions
Leuprolide + Solifenacin
Severity: Moderate
Leuprolide and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can prolong the QT interval, and solifenacin has a dose-related QT effect. Combined use may add to arrhythmia risk, mainly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Leuprolide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with androgen deprivation therapy affecting cardiac repolarization.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors and repeat if other QT-prolonging drugs are added. Use the lowest effective solifenacin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Solifenacin?
MediHelp rates the interaction as moderate. Leuprolide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide can prolong the QT interval, and solifenacin has a dose-related QT effect. Combined use may add to arrhythmia risk, mainly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Leuprolide and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors and repeat if other QT-prolonging drugs are added. Use the lowest effective solifenacin dose.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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