Drug interactions
Leuprolide + Vemurafenib
Severity: Major
Leuprolide and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib causes concentration-dependent QT prolongation, and leuprolide may contribute further. Together they raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Leuprolide and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leuprolide belongs to Endocrine; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation from androgen deprivation (leuprolide) and vemurafenib effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor the QTc during therapy, and correct electrolytes. Interrupt or reduce vemurafenib according to labeling if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Leuprolide with Vemurafenib?
MediHelp rates the interaction as major. Leuprolide and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib causes concentration-dependent QT prolongation, and leuprolide may contribute further. Together they raise the risk of ventricular arrhythmia.
How serious is the interaction between Leuprolide and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during therapy, and correct electrolytes. Interrupt or reduce vemurafenib according to labeling if the QTc becomes markedly prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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