Drug interactions
Leuprolide + Voriconazole
Severity: Moderate
Leuprolide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can prolong the QT interval, and androgen deprivation therapy with leuprolide may also lengthen QT. Taken together, the effect on cardiac repolarization may be additive and raise the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Leuprolide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation from both agents.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat the ECG during co-therapy. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Voriconazole?
MediHelp rates the interaction as moderate. Leuprolide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can prolong the QT interval, and androgen deprivation therapy with leuprolide may also lengthen QT. Taken together, the effect on cardiac repolarization may be additive and raise the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Leuprolide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat the ECG during co-therapy. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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