Drug interactions
Leuprolide + Vorinostat
Severity: Moderate
Leuprolide and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can lengthen the QT interval, and vorinostat has also been associated with QTc changes. Used together, the effect on repolarization may be additive, raising the chance of arrhythmia in susceptible patients.
What this interaction means in plain words
Leuprolide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation, with leuprolide acting through androgen deprivation.
What to do
Obtain a baseline ECG and check potassium and magnesium before starting. Repeat the ECG periodically and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Leuprolide with Vorinostat?
MediHelp rates the interaction as moderate. Leuprolide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide can lengthen the QT interval, and vorinostat has also been associated with QTc changes. Used together, the effect on repolarization may be additive, raising the chance of arrhythmia in susceptible patients.
How serious is the interaction between Leuprolide and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium and magnesium before starting. Repeat the ECG periodically and correct electrolyte abnormalities.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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