Drug interactions
Levamlodipine + Melatonin
Severity: Moderate
Levamlodipine and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin may blunt the blood pressure lowering of dihydropyridine calcium channel blockers, as suggested by limited data with nifedipine. Blood pressure control with levamlodipine could be reduced.
What this interaction means in plain words
Levamlodipine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levamlodipine belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Possible pharmacodynamic antagonism of dihydropyridine effect; mechanism not well established.
What to do
Monitor blood pressure when melatonin is started or stopped. Adjust levamlodipine dose if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Melatonin?
MediHelp rates the interaction as moderate. Levamlodipine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Melatonin may blunt the blood pressure lowering of dihydropyridine calcium channel blockers, as suggested by limited data with nifedipine. Blood pressure control with levamlodipine could be reduced.
How serious is the interaction between Levamlodipine and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when melatonin is started or stopped. Adjust levamlodipine dose if control deteriorates.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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