Drug interactions
Levoketoconazole + Linagliptin
Severity: Minor
Levoketoconazole and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and P-gp inhibitor. Ketoconazole raised linagliptin exposure several-fold in studies, but without a clinically important safety signal at the usual dose.
What this interaction means in plain words
Levoketoconazole and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces linagliptin metabolism and efflux.
What to do
No linagliptin dose adjustment is required; monitor for hypoglycemia if other glucose-lowering agents are used, since levoketoconazole itself may alter glycemia in Cushing's syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Linagliptin?
MediHelp rates the interaction as minor. Levoketoconazole and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a strong CYP3A4 inhibitor and P-gp inhibitor. Ketoconazole raised linagliptin exposure several-fold in studies, but without a clinically important safety signal at the usual dose.
How serious is the interaction between Levoketoconazole and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose adjustment is required; monitor for hypoglycemia if other glucose-lowering agents are used, since levoketoconazole itself may alter glycemia in Cushing's syndrome.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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