Drug interactions
Levoketoconazole + Modafinil
Severity: Moderate
Levoketoconazole and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may raise modafinil concentrations, increasing adverse effects. It also prolongs the QT interval, adding a cardiac consideration if modafinil causes palpitations.
What this interaction means in plain words
Levoketoconazole and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Modafinil belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by levoketoconazole reduces modafinil metabolism.
What to do
Monitor for modafinil adverse effects and consider reducing the modafinil dose while the two are combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Modafinil?
MediHelp rates the interaction as moderate. Levoketoconazole and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may raise modafinil concentrations, increasing adverse effects. It also prolongs the QT interval, adding a cardiac consideration if modafinil causes palpitations.
How serious is the interaction between Levoketoconazole and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects and consider reducing the modafinil dose while the two are combined.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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