Drug interactions
Levoketoconazole + Sotalol
Severity: Contraindicated
Levoketoconazole and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole prolongs the QT interval in a dose-related fashion and its labeling contraindicates use with other QT-prolonging drugs that are CYP3A4 substrates or that cause torsades. Combined with sotalol, the risk of torsades de pointes is substantially increased.
What this interaction means in plain words
Levoketoconazole and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation through IKr channel blockade.
What to do
Avoid the combination; consider alternative cortisol-lowering therapy or an alternative antiarrhythmic or beta-blocker. If it cannot be avoided, specialist supervision with ECG and electrolyte monitoring is essential.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Sotalol?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole prolongs the QT interval in a dose-related fashion and its labeling contraindicates use with other QT-prolonging drugs that are CYP3A4 substrates or that cause torsades. Combined with sotalol, the risk of torsades de pointes is substantially increased.
How serious is the interaction between Levoketoconazole and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider alternative cortisol-lowering therapy or an alternative antiarrhythmic or beta-blocker. If it cannot be avoided, specialist supervision with ECG and electrolyte monitoring is essential.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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