Drug interactions
Levoketoconazole + Vortioxetine
Severity: Moderate
Levoketoconazole and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can modestly raise vortioxetine exposure, although vortioxetine is cleared mainly by CYP2D6. Levoketoconazole also prolongs the QT interval, which adds to the tolerability concern. Higher vortioxetine levels may increase nausea and other dose-related adverse effects.
What this interaction means in plain words
Levoketoconazole and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated minor metabolic pathways of vortioxetine by levoketoconazole.
What to do
Monitor for vortioxetine adverse effects such as nausea and consider a dose reduction if intolerance develops. Obtain ECG and electrolyte monitoring as required for levoketoconazole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Vortioxetine?
MediHelp rates the interaction as moderate. Levoketoconazole and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can modestly raise vortioxetine exposure, although vortioxetine is cleared mainly by CYP2D6. Levoketoconazole also prolongs the QT interval, which adds to the tolerability concern. Higher vortioxetine levels may increase nausea and other dose-related adverse effects.
How serious is the interaction between Levoketoconazole and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vortioxetine adverse effects such as nausea and consider a dose reduction if intolerance develops. Obtain ECG and electrolyte monitoring as required for levoketoconazole therapy.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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