Drug interactions
Levomilnacipran + Posaconazole
Severity: Moderate
Levomilnacipran and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises levomilnacipran exposure, which may increase adverse effects such as nausea, increased heart rate, blood pressure elevation and serotonergic effects.
What this interaction means in plain words
Levomilnacipran and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces levomilnacipran clearance.
What to do
Do not exceed 80 mg daily of levomilnacipran during posaconazole use. Monitor blood pressure, heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Posaconazole?
MediHelp rates the interaction as moderate. Levomilnacipran and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole raises levomilnacipran exposure, which may increase adverse effects such as nausea, increased heart rate, blood pressure elevation and serotonergic effects.
How serious is the interaction between Levomilnacipran and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed 80 mg daily of levomilnacipran during posaconazole use. Monitor blood pressure, heart rate and tolerability.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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