Drug interactions
Linagliptin + Lopinavir
Severity: Minor
Linagliptin and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir inhibits CYP3A4 and P-gp, which may modestly raise linagliptin levels without much clinical impact. Protease inhibitors may also cause insulin resistance and hyperglycemia, opposing glycemic control.
What this interaction means in plain words
Linagliptin and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4/P-gp inhibition may increase linagliptin exposure, while protease inhibitor-related insulin resistance antagonizes its effect.
What to do
No linagliptin dose change is needed; monitor blood glucose and HbA1c during antiretroviral therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Linagliptin with Lopinavir?
MediHelp rates the interaction as minor. Linagliptin and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir-boosted lopinavir inhibits CYP3A4 and P-gp, which may modestly raise linagliptin levels without much clinical impact. Protease inhibitors may also cause insulin resistance and hyperglycemia, opposing glycemic control.
How serious is the interaction between Linagliptin and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose change is needed; monitor blood glucose and HbA1c during antiretroviral therapy.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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