Drug interactions
Linagliptin + Nevirapine
Severity: Moderate
Linagliptin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong inducers of CYP3A4 and P-gp reduce linagliptin exposure and may weaken glycemic control. Nevirapine is a moderate inducer, so the effect is likely less than with rifampicin.
What this interaction means in plain words
Linagliptin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 and possibly P-glycoprotein, lowering linagliptin concentrations.
What to do
Monitor blood glucose and HbA1c and consider an alternative or additional antidiabetic agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Linagliptin with Nevirapine?
MediHelp rates the interaction as moderate. Linagliptin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong inducers of CYP3A4 and P-gp reduce linagliptin exposure and may weaken glycemic control. Nevirapine is a moderate inducer, so the effect is likely less than with rifampicin.
How serious is the interaction between Linagliptin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and consider an alternative or additional antidiabetic agent if control worsens.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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