Drug interactions
Linagliptin + Rucaparib
Severity: Minor
Linagliptin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly to moderately and might increase linagliptin exposure. Because most linagliptin is eliminated unchanged, the effect is expected to be small.
What this interaction means in plain words
Linagliptin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
CYP3A4 inhibition by rucaparib reduces the minor metabolic clearance of linagliptin.
What to do
No routine dose change; monitor for hypoglycemia and adverse effects if other antidiabetic drugs are co-prescribed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Linagliptin with Rucaparib?
MediHelp rates the interaction as minor. Linagliptin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly to moderately and might increase linagliptin exposure. Because most linagliptin is eliminated unchanged, the effect is expected to be small.
How serious is the interaction between Linagliptin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for hypoglycemia and adverse effects if other antidiabetic drugs are co-prescribed.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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