Drug interactions
Linagliptin + Stiripentol
Severity: Minor
Linagliptin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-gp, so linagliptin exposure could shift in either direction. Linagliptin is mostly eliminated unchanged, so significant changes are unlikely.
What this interaction means in plain words
Linagliptin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition/induction and P-gp inhibition by stiripentol may alter linagliptin disposition.
What to do
No empiric adjustment; monitor glycemic control and adverse effects when stiripentol is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Linagliptin with Stiripentol?
MediHelp rates the interaction as minor. Linagliptin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits and induces CYP3A4 and inhibits P-gp, so linagliptin exposure could shift in either direction. Linagliptin is mostly eliminated unchanged, so significant changes are unlikely.
How serious is the interaction between Linagliptin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment; monitor glycemic control and adverse effects when stiripentol is started or stopped.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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