Drug interactions
Liothyronine + Omeprazole
Severity: Minor
Liothyronine and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acidity can impair absorption of oral thyroid hormones, mostly documented with levothyroxine. For liothyronine the evidence is conflicting and any effect is probably small.
What this interaction means in plain words
Liothyronine and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liothyronine belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH may modestly reduce oral thyroid hormone absorption.
What to do
Check TSH and clinical thyroid status after starting or stopping long-term omeprazole and adjust the liothyronine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Omeprazole?
MediHelp rates the interaction as minor. Liothyronine and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acidity can impair absorption of oral thyroid hormones, mostly documented with levothyroxine. For liothyronine the evidence is conflicting and any effect is probably small.
How serious is the interaction between Liothyronine and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH and clinical thyroid status after starting or stopping long-term omeprazole and adjust the liothyronine dose if needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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