Drug interactions
Liposomal doxorubicin + Tucatinib
Severity: Moderate
Liposomal doxorubicin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and P-gp and may modestly increase doxorubicin exposure. CYP3A4 is a minor route, so the effect is probably limited, but toxicity could increase.
What this interaction means in plain words
Liposomal doxorubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4 and P-glycoprotein, potentially reducing doxorubicin clearance.
What to do
Monitor blood counts and cardiac status, and reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Liposomal doxorubicin with Tucatinib?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and P-gp and may modestly increase doxorubicin exposure. CYP3A4 is a minor route, so the effect is probably limited, but toxicity could increase.
How serious is the interaction between Liposomal doxorubicin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status, and reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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