Drug interactions
Liraglutide + Medroxyprogesterone
Severity: Moderate
Liraglutide and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Medroxyprogesterone, especially the depot injection, can worsen glucose tolerance and may reduce the effect of liraglutide in diabetic patients. Weight gain with long-term use may further affect control.
What this interaction means in plain words
Liraglutide and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: progestin-related insulin resistance and impaired glucose tolerance.
What to do
Monitor blood glucose and HbA1c during treatment with medroxyprogesterone. Adjust the antidiabetic regimen if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Liraglutide with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Liraglutide and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Medroxyprogesterone, especially the depot injection, can worsen glucose tolerance and may reduce the effect of liraglutide in diabetic patients. Weight gain with long-term use may further affect control.
How serious is the interaction between Liraglutide and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during treatment with medroxyprogesterone. Adjust the antidiabetic regimen if control deteriorates.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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