Drug interactions
Liraglutide + Prochlorperazine
Severity: Moderate
Liraglutide and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can disturb glucose regulation, with reports of both hyperglycemia and hypoglycemia, which may offset or distort the glucose-lowering effect of liraglutide. Glycemic control may therefore become less predictable.
What this interaction means in plain words
Liraglutide and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition: phenothiazines may alter insulin secretion and peripheral glucose handling, while liraglutide lowers glucose through GLP-1 receptor agonism.
What to do
Monitor blood glucose more frequently when prochlorperazine is started, changed or stopped. Adjust the antidiabetic regimen based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Prochlorperazine?
MediHelp rates the interaction as moderate. Liraglutide and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines can disturb glucose regulation, with reports of both hyperglycemia and hypoglycemia, which may offset or distort the glucose-lowering effect of liraglutide. Glycemic control may therefore become less predictable.
How serious is the interaction between Liraglutide and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when prochlorperazine is started, changed or stopped. Adjust the antidiabetic regimen based on readings.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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