Drug interactions
Lisdexamfetamine + Magnesium oxide
Severity: Minor
Lisdexamfetamine and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium oxide can modestly alkalinize the urine, which reduces renal excretion of amphetamine, the active metabolite of lisdexamfetamine. This may prolong and intensify stimulant effects such as insomnia, tachycardia and anxiety.
What this interaction means in plain words
Lisdexamfetamine and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Urinary alkalinization increases tubular reabsorption of amphetamine and reduces its renal clearance.
What to do
Monitor for increased stimulant effects when starting or regularly using magnesium antacids. Reduce the lisdexamfetamine dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Lisdexamfetamine with Magnesium oxide?
MediHelp rates the interaction as minor. Lisdexamfetamine and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium oxide can modestly alkalinize the urine, which reduces renal excretion of amphetamine, the active metabolite of lisdexamfetamine. This may prolong and intensify stimulant effects such as insomnia, tachycardia and anxiety.
How serious is the interaction between Lisdexamfetamine and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects when starting or regularly using magnesium antacids. Reduce the lisdexamfetamine dose if adverse effects appear.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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