Drug interactions
Lisdexamfetamine + Methylphenidate
Severity: Moderate
Lisdexamfetamine and Methylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CNS stimulants that raise catecholamine activity, so together they can cause additive increases in blood pressure and heart rate, agitation, insomnia and anxiety. Concurrent use is generally not recommended and increases the risk of cardiovascular adverse effects.
What this interaction means in plain words
Lisdexamfetamine and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Methylphenidate belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic sympathomimetic effects from increased synaptic dopamine and norepinephrine.
What to do
Avoid routine combination of two stimulants. If used together, monitor blood pressure, heart rate and sleep and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Methylphenidate?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CNS stimulants that raise catecholamine activity, so together they can cause additive increases in blood pressure and heart rate, agitation, insomnia and anxiety. Concurrent use is generally not recommended and increases the risk of cardiovascular adverse effects.
How serious is the interaction between Lisdexamfetamine and Methylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of two stimulants. If used together, monitor blood pressure, heart rate and sleep and use the lowest effective doses.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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