Drug interactions
Lisdexamfetamine + Nabilone
Severity: Moderate
Lisdexamfetamine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone is sedating while lisdexamfetamine is stimulating, so the net effect on alertness is unpredictable. Both can raise heart rate, and nabilone may worsen anxiety or agitation in patients taking stimulants.
What this interaction means in plain words
Lisdexamfetamine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Opposing CNS effects with additive tachycardia from cannabinoid and amphetamine sympathomimetic actions.
What to do
Monitor heart rate, blood pressure and anxiety or mood symptoms. Do not use one drug to offset the effects of the other.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Nabilone?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone is sedating while lisdexamfetamine is stimulating, so the net effect on alertness is unpredictable. Both can raise heart rate, and nabilone may worsen anxiety or agitation in patients taking stimulants.
How serious is the interaction between Lisdexamfetamine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and anxiety or mood symptoms. Do not use one drug to offset the effects of the other.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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